TÉLÉCHARGER 3310 MADD

TÉLÉCHARGER 3310 MADD

TÉLÉCHARGER 3310 MADD

T3 is O, S, or Se; each of R13a and R13b is, independently, H, optionally substituted acyl, optionally substituted alkyl, or optionally substituted alkoxy, wherein the combination of R13b and R14 can be taken together to form optionally substituted heterocyclyl; R14' is, independently, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heterocyclyl, optionally substituted alkheterocyclyl, optionally substituted alkaryl, optionally substituted aminoalkyl, optionally substituted alkoxy, optionally substituted alkoxycarbonylalkyl, optionally substituted alkoxycarbonylalkoxy, optionally substituted carboxyalkoxy, optionally substituted carboxyalkyl, or optionally substituted carbamoylalkyl; and each R15 is, independently, H, optionally substituted alkyl, optionally substituted alkenyl, or optionally substituted alkynyl. The isolated polynucleotide of any one of claims , further comprising a targeting moiety, wherein said targeting moiety is covalently bound to said polynucleotide. The isolated polynucleotide of claim 36, wherein said targeting moiety is an antibody, thyrotropin, melanotropin, lectin, glycoprotein, surfactant protein A, Mucin carbohydrate, multivalent lactose, multivalent galactose, N-acetyl- galactosamine, N- acetyl-gulucosamine multivalent mannose, multivalent fucose, glycosylated polyaminoacids, multivalent galactose, transferrin, bisphosphonate, polyglutamate, polyaspartate, a lipid, cholesterol, a steroid, bile acid, folate, vitamin B12, biotin, an RGD peptide, an RGD peptide mimetic, or an aptamer. A pharmaceutical composition comprising the isolated polynucleotide of any one A pharmaceutical composition comprising the isolated polynucleotide of any one of claims and a pharmaceutically acceptable excipient.

Nom: 3310 madd
Format:Fichier D’archive
Version:Dernière
Licence:Libre!
Système d’exploitation: MacOS. iOS. Windows XP/7/10. Android.
Taille:50.81 Megabytes

Madd 2019 Black 2019

A method of producing a polypeptide of interest in a mammalian cell, tissue or organism comprising administering to said cell, tissue or organism the isolated polynucleotide of any one of claims or the pharmaceutical composition of any of The method of claim 42, wherein the isolated polynucleotide is formulated. The method of claim 44, wherein the isolated polynucleotide is administered at a total daily dose of between 1 ug and ug.

The method of claim 45, wheriein administration is by injection. The method of claim 46, wherein administration is intradermal or subcutaneous or The method of claim 44, wherein the resulting polynucleotide formulation has a mean particle size of 80 nm nm, a PDI of between 0. A method for producing an increased level of a polypeptide of interest selected from the group consisting of SEQ ID NOs in a mammalian cell, tissue or organism, comprising administering to said cell, tissue or organism a total daily dose of the isolated polynucleotide of any one of claims or the pharmaceutical composition of any one of claims in two or more equal or unequal split doses.

The method of claim 52, wherein the level of the polypeptide produced in response to said administration is greater than the levels produced by administering the same total daily dose of the isolated polynucleotide or pharmaceutical composition as a The method of claim 52, wherein the mammalian organism is a human patient in need of an increased level of the polypeptide of interest. The method of claim 54, wherein the increased level of the polypeptide of interest is detectable in a bodily fluid of said patient.

The method of claim 55, wherein the bodily fluid is selected from the group consisting of peripheral blood, serum, plasma, ascites, urine, cerebrospinal fluid CSF , sputum, saliva, bone marrow, synovial fluid, aqueous humor, amniotic fluid, cerumen, breast milk, broncheoalveolar lavage fluid, semen, prostatic fluid, cowper's fluid or pre- ejaculatory fluid, sweat, fecal matter, hair, tears, cyst fluid, pleural and peritoneal fluid, pericardial fluid, lymph, chyme, chyle, bile, interstitial fluid, menses, pus, sebum, vomit, vaginal secretions, mucosal secretion, stool water, pancreatic juice, lavage fluids from sinus cavities, bronchopulmonary aspirates, blastocyl cavity fluid, and umbilical cord The method of claim 56, wherein the bodily fluid is serum and the polpeptide per unit drug PUD is greater than 1.

The method of claim 57, wherein the dose splitting factor DSF is greater than 4. The method of claim 55, wherein administration is transdermal.

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The method of claim 59, wherein transdermal administration comprises utilization of one or more members selected from the group consisting of a patch, cream, ointment, mechanical device, needle, sponge, depot and fabric.

The method of claim 59, wherein administration is according to a dosing regimen which occurs over the course of hours, days, weeks, months, or years. Various aspects include methods and devices for displaying advertisements on a mobile advertising display device MADD.

Selon divers aspects, la présente invention concerne des procédés et dispositifs pour l'affichage de publicités sur un dispositif mobile d'affichage publicitaire MADD. Every newspaper in my constituency carried my article in support of MADD.

Tous les journaux de ma circonscription ont fait paraître mon article en faveur de MADD.

MADD will have to do their fundraising in a new culture. MADD devra effectuer ses collectes de fonds dans un nouvel environnement.

Yet MADD has not been getting enough co-operation from the federal government. MADD ne réussit pourtant pas à obtenir la collaboration du gouvernement fédéral.

Especially at Christmas, MADD reminds us with a red ribbon campaign of the tragic consequences of drinking and driving. C'est à l'époque de Noël que MADD fait le plus pour nous rappeler les tragiques conséquences que peut avoir la conduite en état d'ébriété.

MADD says that current practices are making a mockery of the Canadian judicial system.

MADD affirme que les pratiques actuelles tournent en ridicule le système judiciaire canadien. Par exemple, une part importante des revenus de l'association Les mères contre l'alcool au volant, ou MADD , provient de la sollicitation téléphonique. Je tiens à répéter que le conseil national de MADD Canada, nos sections locales et nos membres appuient de tout coeur le projet de loi C